Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization
نویسندگان
چکیده
منابع مشابه
Simvastatin suppresses breast cancer cell proliferation induced by senescent cells.
Cellular senescence suppresses cancer by preventing the proliferation of damaged cells, but senescent cells can also promote cancer though the pro-inflammatory senescence-associated secretory phenotype (SASP). Simvastatin, an HMG-coA reductase inhibitor, is known to attenuate inflammation and prevent certain cancers. Here, we show that simvastatin decreases the SASP of senescent human fibroblas...
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ژورنال
عنوان ژورنال: Translational Oncology
سال: 2020
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2020.100867